Journal Article
Developing an Ovine Model of Impact Traumatic Brain Injury
2023-09-20
Abstract Traumatic brain injury is a leading cause of global death and disability. Clinically relevant large animal models are a vital tool for understanding the biomechanics of injury, providing validation data for computation models, and advancing clinical translation of laboratory findings. It is well-established that large angular accelerations of the head can cause TBI, but the effect of head impact on the extent and severity of brain pathology remains unclear. Clinically, most TBIs occur with direct head impact, as opposed to inertial injuries where the head is accelerated without direct impact. There are currently no active large animal models of impact TBI. Sheep may provide a valuable model for studying TBI biomechanics, with relatively large brains that are similar in structure to that of humans. The aim of this project is to develop an ovine model of impact TBI to study the relationships between impact mechanics and brain pathology.